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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/11135

Title: Next Generation Lanthanide-based Contrast Agents for Applications in MRI, Multimodal Imaging, and Anti-cancer Therapies
Authors: Chaudhary, Richa
Advisor: Prosser, Robert Scott
Department: Chemistry
Keywords: gadolinium
MRI
nanoparticle
imaging
contrast agent
relaxivity
Issue Date: 30-Jul-2008
Abstract: A new class of polymer stabilized gadolinium trifluoride nanoparticles (NPs) have been developed as contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT), with potential long term goals in targeted imaging and anti-cancer therapy. The NPs are comprised of a 90/10 mixture of GdF3/EuF3 and are coated with linear polyacrylic acid (PAA) chains consisting of 25 repeating units. The resulting aggregates are stable in serum and possess unprecedented mass relaxivities [i.e. ~100-200 s-1(mg/mL)-1]. Electron microscopy images reveal various NP morphologies which depend on the exact synthesis protocol. These include highly cross-linked oblong clusters with 30-70 nm cross sections, extensively cross-linked aggregates with 100-300 nm cross sections, and distinct polymer stabilized nanocrystals with 50 nm diameters. Their application as contrast agents in T1-weighted MRI studies, CT imaging at various X-ray energies, and preliminary rat brain perfusion studies was also tested. NP contrast enhancement was compared to Gd-DPTA (Magnevist®) and iopramide (Ultravist 300®) to demonstrate their high contrasting properties and potential as multimodal contrast agents.
URI: http://hdl.handle.net/1807/11135
Appears in Collections:Master
Department of Chemistry - Master theses

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