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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/11148

Title: Development of a Novel Biodegradable Drug Polymer for the Modification of Inflammatory Response
Authors: Khor, Sara
Advisor: Santerre, J. Paul
Department: Biomedical Engineering
Keywords: Drug delivery
Issue Date: 30-Jul-2008
Abstract: The first objective of this thesis was to assess the feasibility of designing a “smart” degradable polymer that can release anti-inflammatory drugs in response to inflammatory-related enzymes. The drug polymer was synthesized using diisocyanates, poly(caprolactone)diols, and oxaceprol (OC) biomonomers. Biodegradation studies demonstrated that the trimethylhexamethylene diisocyanate-based drug polymer responded to an inflammatory enzyme to release more OC, while a 1, 12-diisocyanatododecane analog demonstrated minimal drug release. The drug delivery response was believed to be a direct function of the molecular structure and distribution of the hard segment. The second objective of this thesis was to elucidate the anti-inflammatory mechanisms of OC by investigating its effects on cytokine-induced monocytic-cells adhesion in human umbilical vein endothelial cells (HUVECs) in vitro. Results showed that OC had no direct effect on the monocyte-endothelium adhesion, suggesting that OC may mediate inflammation by mechanisms other than those suggested by the literature.
URI: http://hdl.handle.net/1807/11148
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

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