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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/11176

Title: Calcium Phosphate Cements Loaded with Pantoprazole as Novel Bone Substitutes
Authors: Furtado Araujo, Michel Victor
Advisor: Davies, John Edward
Department: Dentistry
Keywords: calcium phosphate cements
bone substitutes
proton pump inhibitors
bone healing
Issue Date: 30-Jul-2008
Abstract: Calcium phosphate cements are produced by the mixing of calcium phosphate powders in an aqueous solution resulting in a low-temperature synthesized hydroxyapatite. They have been used as bone substitutes and drug delivery systems. The present work examined the possibility of a machine-based modification to this process to derive a standardized preparation method of calcium phosphate cements that could be loaded with Pantoprazole. To examine the characteristics of these novel materials, the following analyses of hand- and machine-made cements, with and without Pantoprazole were undertaken: in vitro surface characterization, dissolution, hydroxyapatite conversion, Pantoprazole delivery, as well as in vivo reparative bone formation and particulate degradation. The in vitro surface characterization, dissolution at different pHs, and drug release analyses showed insignificant differences between hand- and machine-prepared cements. However, machine-made cements showed increased hydroxyapatite conversion, decreased dissolution at pH 7.4, and better in vivo outcomes than commercially available bone-substitute particulate biomaterials.
URI: http://hdl.handle.net/1807/11176
Appears in Collections:Master
Faculty of Dentistry - Master theses

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