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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/118

Title: Safety evaluation of transgenic potatoes transformed with synthetic antibacterial peptide gene - toxicological test
Authors: Wang, Ying
Qiu, Jinsong
Sun, Yibin
Qu, Xianming
Tang, Yixiong
Jia, Shirong
Keywords: release GMO
Issue Date: May-1997
Publisher: Biostrategy Associates
Citation: BioSafety Journal 3(1)
Abstract: Cecropin B is an antibacterial peptide commonly existing in the insect immune system. During the past decade, we have designed and synthesized various novel antibacterial peptides and corresponding genes, such as modified Cecropin B, Shiva A and Shiva 2A (an analog of Cecropin B with 40% of amino acid sequence homology) and WHD. 3 clones with significant enhanced resistance to bacterial wilt (caused by Pseudomonas solanacearum) have been obtained. As part of the biosafety assessment of the transgenic potato, here we report the results of toxicological tests obtained using the synthetic peptide Shiva 2A. The acute toxicity study used the Ames, micronucleus and chromosome aberration tests together with accumulative toxicity to mice.
URI: http://hdl.handle.net/1807/118
Appears in Collections:Bioline International Legacy Collection

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