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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/1522

Title: Full Length Research Paper - Some genetic characteristics of sabin-like poliovirus isolated from acute flaccid paralysis cases in Nigeria
Authors: Adu, Festus Doyin
Iber, Jane
Harry, Tekena
Burns, Cara
Oyedele, Oluseyi
Adeniji, Johnson Adekunle
Ossei-Kwasi, Mubarak
Kilpatrick, David
Tomori, Oyewale
Kew, Olen
Issue Date: Nov-2003
Publisher: Academic Journals
Citation: African Journal of Biotechnology 2(11)
Abstract: A total of 34 sabin strains of the poliovirus isolated from 22 children with 60-day follow-up residual acute flaccid paralysis (AFP) were genetically characterized and screened for any form of recombination. Sequence analysis of the 906-nucleotide capsid showed that all the isolates were similar to their original sabin serotypes, however two of the viruses had drifted in their 3D noncapsid regions toward a sabin-sabin and sabin-nonpolio entero combination. Routine immunization in Nigeria is low and in spite of the increase in the frequency of supplemental immunizations, a lot of children are still inadequately immunized, which may be the reason for our observation in this study. Although we are not dealing with a case of circulating vaccine derived poliovirus (cVDPV) yet, if the above condition persists, the advent of cVDVP may not be too far. There is therefore the need to maintain a high quality mass immunization and sustained routine immunization.
URI: http://bioline.utsc.utoronto.ca/archive/00000666/02/jb03091.pdf
Appears in Collections:Bioline International Legacy Collection

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