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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/16713

Title: Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease.
Authors: Tang, JK
Moro, E
Mahant, N
Hutchison, WD
Lang, AE
Lozano, AM
Dostrovsky, JO
Department: Physiology
Keywords: Basal Ganglia
Movement Disorders
Spasmodic Torticollis
Single-unit Recording
Cervical Dystonia
Parkinson's Disease
Deep Brain Stimulation
Globus Pallidus Internus
Issue Date: Aug-2007
Publisher: Journal of Neurophysiology
Citation: Tang JK, Moro E, Mahant N, Hutchison WD, Lang AE, Lozano AM, Dostrovsky JO. Neuronal firing rates and patterns in the globus pallidus internus of patients with cervical dystonia differ from those with Parkinson's disease. J Neurophysiol 2007 Aug;98(2):720-9. Epub 2007 May 30.
Abstract: Cervical dystonia (CD) is a movement disorder that involves involuntary turning and twisting of the neck caused by abnormal muscle contraction. Deep brain stimulation (DBS) in the globus pallidus internus (GPi) is used to treat both CD and the motor symptoms of Parkinson's disease (PD). It has been suggested that the differing motor symptoms in CD and PD may arise from a decreased GPi output in CD and elevation of output in PD. To test this hypothesis, extracellular recordings of GPi neuronal activity were obtained during stereotactic surgery for the implantation of DBS electrodes in seven idiopathic CD and 14 PD patients. The mean GPi neuronal firing rate recorded from CD patients was lower than that in PD patients (P < 0.001; means +/- SE: 71.4 +/- 2.2 and 91.7 +/- 3.0 Hz, respectively). Furthermore, GPi neurons fired in a more irregular pattern consisting of more frequent and longer pauses in CD compared with PD patients. When comparisons were done based on locations of recordings, these differences in firing rates and patterns were limited to the ventral portion of the GPi. In contrast, no difference in firing rate or pattern was observed in the globus pallidus externus between the two groups. These findings suggest that alterations in both firing rate and firing pattern may underlie the differing motor symptoms associated with these two movement disorders.
URI: http://hdl.handle.net/1807/16713
ISSN: 0022-3077
Appears in Collections:Faculty Publications

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