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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17181

Title: The Relationship Between Adult Hippocampal Neurogenesis and Spatial Learning and Memory in Natural Populations of Food-storing Red Squirrels (Tamiasciurus hudsonicus).
Authors: Johnson, Kristin Margaret
Advisor: Wojtowicz, Jan Martin
Boonstra, Rudy
Department: Physiology
Keywords: adult neurogenesis
hippocampus
dentate gyrus
spatial learning and memory
red squirrels
food-storing
immunohistochemistry
Ki-67
DCX
NeuN
Issue Date: 24-Feb-2009
Abstract: Previous research on the relationship between spatial memory and adult hippocampal neurogenesis has been controversial. In the present study, neurogenesis was compared between two natural populations of the same species that differ in their reliance on spatial memory to cache and retrieve stored food. Western red squirrels store food in a single site whereas eastern red squirrels store food in multiple sites. Neurogenesis was assessed using endogenous markers of the number of proliferating cells (Ki-67) and the number of immature neurons (DCX), and neuronal recruitment was determined by measuring the area of the dentate gyrus of the hippocampus. The number of proliferating cells, immature neurons and neuronal recruitment were enhanced in the eastern compared to the western red squirrels, reflecting the food storing strategies used by the squirrels. This suggests that there is a positive correlation between adult hippocampal neurogenesis and spatial learning and memory.
URI: http://hdl.handle.net/1807/17181
Appears in Collections:Master
Department of Physiology - Master theses

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