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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17212

Title: The Role of GABAA Receptor-mediated Neurotransmission in Ventilatory Acclimatisation to Hypoxia
Authors: Phe, Balinda Siou Ing
Advisor: Reid, Stephen G.
Department: Cell and Systems Biology
Keywords: GABAA
Chronic Hypoxia
Issue Date: 26-Feb-2009
Abstract: Exposure to chronic hypoxia (CH) leads to ventilatory acclimatisation to hypoxia (VAH) which is a time-dependent increase in breathing. This study examined the role of the GABAA receptor in establishing VAH. Rats were exposed to CH or control (normoxic) conditions for 10 days during which the GABAA receptor antagonist, bicuculline, was infused systemically or directly into the nucleus of the solitary tract (NTS). Acute breathing trials were then performed to measure resting ventilation and ventilatory chemoreflexes. Systemic administration of bicuculline caused reductions in breathing during acute hypoxia and acute hypercapnia in the control but not the CH animals. Continuous infusion of bicuculline in to the NTS caused a reduction in the acute hypoxic ventilatory response in animals exposed to CH but not in the control animals. The results indicate that exposure to CH alters the GABAA-mediated regulation of acute ventilatory chemoreflexes both in the NTS and elsewhere in the brain.
URI: http://hdl.handle.net/1807/17212
Appears in Collections:Master
Department of Cell and Systems Biology - Master theses

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