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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17441

Title: Delayed Oxidative Injury to the Superior Colliculus and Retinal Changes After Cerebral Hypoperfusion/Reperfusion Injury
Authors: Ramsaroop, Lynzey
Advisor: Yucel, Yeni
Gupta, Neeru
Department: Laboratory Medicine and Pathobiology
Keywords: bilateral common carotid artery occlusion
superior colliculus
retinal ganglion cell
Issue Date: 14-Jul-2009
Abstract: Damage to visual pathways can lead to irreversible blindness. Posterior visual pathways, located within a watershed area, are predisposed to hypoperfusion/reperfusion injury. In a novel rat model of bilateral common carotid artery occlusion (BCCAO), oxidative injury to the superior colliculus (SC), a major visual center within the watershed area was evaluated, in addition to its effects on retinal ganglion cells (RGCs). Nitrotyrosine, a footprint of peroxynitrite-mediated oxidative injury in the SC, and microtubule-associated protein 2, a dendrite marker in the retina, were assessed using immunofluorescence and confocal microscopy. Nitrotyrosine-immunoreactivity in the SC was increased 2 weeks after BCCAO compared to controls. Microtubule-associated protein 2-immunoreactivity in the central inner plexiform layer was reduced 3 weeks after BCCAO compared to controls. Global incomplete cerebral hypoperfusion/reperfusion induced oxidative injury in the SC and retrograde RGC dendritic changes. This suggests that cerebrovascular injury affecting the posterior visual pathways may contribute to vision loss in patients.
URI: http://hdl.handle.net/1807/17441
Appears in Collections:Master
Department of Laboratory Medicine and Pathobiology - Master theses

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