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T-Space at The University of Toronto Libraries >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17445

Title: Luminescence Contact Imaging Microsystems
Authors: Singh, Ritu
Advisor: Genov, Roman
Department: Electrical and Computer Engineering
Keywords: Chemiluminescence
CMOS imager
Electrochemiluminescence
Fluorescence
data converters
analog-to-digital converters
microfluidics
Issue Date: 14-Jul-2009
Abstract: This thesis presents two hybrid luminescence-based biochemical photosensory microsystems: a CMOS/microfluidic chemiluminescence contact imager, and a CMOS/thin-film fluorescence contact imager. A compact, low-power analog-to-digital converter (ADC) architecture for use in such sensory microsystems is also proposed. Both microsystems are prototyped in a standard 0.35um CMOS technology. The CMOS/microfluidic microsystem integrates a 64x128-pixel CMOS imager and a soft polymer microfluidic network. Circuit techniques are employed to reduce the dark current and circuit noise for low-level light sensitivity. Experimental validation is performed by detecting luminol chemiluminescence and electrochemiluminescence. The CMOS/thin-film microsystem integrates an existing 128x128-pixel CMOS imager and a prefabricated, high-performance optical filter. Experimental validation is performed by detecting human DNA labeled with Cyanine-3 fluorescent dye. The proposed ADC architecture employs a novel digital-to-analog converter with a flexible trade-off between the integration area and the conversion speed. The area savings and good linearity of the DAC are verified by simulations.
URI: http://hdl.handle.net/1807/17445
Appears in Collections:Master
The Edward S. Rogers Sr. Department of Electrical & Computer Engineering - Master theses

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