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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17517

Title: Understanding Receptor Adaptation And Co-receptor Use For Feline Leukemia Viruses
Authors: Hussain, Naveen
Advisor: Tailor, Chetankumar
Department: Molecular and Medical Genetics
Keywords: Feline Leukemia Virus
Co-receptor
Evolution
Issue Date: 10-Aug-2009
Abstract: Feline leukemia viruses (FeLVs) are pathogenic retroviruses of the domestic cat. FeLV transmission and emergence of pathogenic variants show striking similarity to HIV pathogenesis. The emergence of pathogenic subgroup-C FeLV from the transmitted subgroup-A FeLV coincides with a switch in host receptor used for infection as a result of mutations in the viral envelope protein (Env). I have characterized a novel FeLV Env that may represent an evolutionary intermediate between FeLV-A and FeLV-C. I have also reported evidence suggesting that FeLVs may use co-factors/co-receptors for infection. I have found that FeLVs inefficiently infect murine NIH3T3 cells overexpressing FeLV receptors (NIH3T3/Receptor). I have provided evidence that the low infection is caused by a block at a post-binding but pre-entry stage of FeLV infection. Furthermore, fusion of NIH3T3/Receptor cells with highly susceptible cells rescues inhibition to infection suggesting that FeLVs, like HIV, may also use co-receptors for infection.
URI: http://hdl.handle.net/1807/17517
Appears in Collections:Master
Department of Molecular Genetics - Master theses

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