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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17700

Title: Genomic and Transcriptome Profiling of Serous Epithelial Ovarian Cancer
Authors: Menzies, Rebecca Joanne Zoe
Advisor: Mak, Tak Wah
Department: Medical Biophysics
Keywords: ovarian cancer
copy number variation
Issue Date: 22-Sep-2009
Abstract: Epithelial ovarian cancer is the leading cause of death by gynaecological malignancy. Elucidation of the driver genes of ovarian cancer will lead to treatment targets and tailored therapy for this disease. The Affymetrix Genome-Wide SNP Array 6.0 was used to study 100 serous ovarian samples and 10 normal ovarian samples to identify loci and driver genes. The ovarian cancer genome was found to have high overall genomic instability across all chromosomes and key known genes in this disease were identified in the dataset. Aberrant regions of copy number gain were located in “blocks” of constant copy number at 1p, 1q, 8q, 12p, 19q and 20q. The range in copy number for gains was 4.2 to 5.1. The “blocks” of genes were located at 8p and 5p for copy number losses. The range for copy number loss was 0.6 to 0.9.
URI: http://hdl.handle.net/1807/17700
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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