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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17869

Title: Cytokines and their relationship to the symptoms and outcome of cancer.
Authors: Seruga, B
Zhang, H
Bernstein, LJ
Tannock, IF
Department: Physiology
St. Michael's Hospital
Keywords: cytokines
Issue Date: 1-Nov-2008
Publisher: Nature Reviews Cancer
Citation: Seruga B, Zhang H, Bernstein LJ, Tannock IF. Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer. 2008 Nov;8(11):887-99.
Abstract: Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.
URI: http://hdl.handle.net/1807/17869
ISSN: 1474-175X
Appears in Collections:Faculty Publications

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