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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/17890

Title: Platelets in hemostasis and thrombosis: role of integrins and their ligands
Authors: Ni, H
Freedman, J
Department: Laboratory Medicine and Pathobiology
Physiology
St. Michael's Hospital
Keywords: Platelets
hemostasis
thrombosis
integrins
ligands
Issue Date: 1-Jun-2003
Publisher: Elsevier
Citation: Ni H, Freedman J. Platelets in hemostasis and thrombosis: role of integrins and their ligands. Transfus Apher Sci. 2003;28(3):257-64.
Abstract: Platelet adhesion and aggregation at the site of vascular injury are two key events in hemostasis and thrombosis. The contribution of several platelet receptors and their ligands has been highlighted in these processes. In platelet adhesion, particularly at high shear stress, GP1b-von Willebrand factor (vWF) interaction may initiate this event, which is followed by firm platelet adhesion mediated by members of the integrin family, such as beta1 (alpha2beta1, alpha5beta1) and beta3 (alphaIIbbeta3) integrins. In platelet aggregation, although GP1b-vWF, P selectin-sulfatides, and other molecules, may play some roles, the process is mainly mediated by beta3 (alphaIIbbeta3) integrin and its ligands, such as fibrinogen and vWF. Recent studies with perfusion chambers and intravital microscopy have revised the dogma established with the static (low shear stress) conditions. It is intriguing that platelet adhesion and aggregation do still occur in mice lacking both vWF and fibrinogen, suggesting that other unexpected molecule(s) may also be important in hemostasis and thrombosis.
URI: http://dx.doi.org/10.1016/S1473-0502(03)00044-2
http://hdl.handle.net/1807/17890
ISSN: 1473-0502
Appears in Collections:Faculty Publications

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