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|Title: ||Inhaled Hypertonic Saline (7%) improves the Lung Clearance Index in CF Paediatric Patients with FEV1% predicted ≥ 80%|
|Authors: ||Amin, Reshma|
|Advisor: ||Corey, Mary|
|Department: ||Health Policy, Management and Evaluation|
|Keywords: ||Hypertonic Saline|
|Issue Date: ||14-Dec-2009|
|Abstract: ||Objective: To determine if inhaled Hypertonic Saline (7%) improves the Lung Clearance Index in paediatric Cystic Fibrosis patients with FEV1 ≥80% predicted.
Methods: In a blinded crossover trial, twenty CF patients received 4 weeks of hypertonic saline (7%) (HS) and 4 weeks of isotonic saline (0.9%) (IS) separated by a 4 week washout period. The primary endpoint was the change in LCI in the HS versus the IS treatment periods. Results: Four weeks of twice daily inhalation of HS significantly improved the LCI as compared to IS by 1.16, 95% CI [0.26, 2.05]; p=0.016. Baseline LCI before IS, 8.71+/-2.10, was not significantly different from baseline LCI before HS inhalation, 8.84+/-1.95 (p=0.73). Randomization order had no significant impact on the treatment effect (p=0.61).
Conclusions: Four weeks of twice daily Hypertonic Saline (7%) inhalations improved the LCI and may be a suitable early intervention therapy for CF patients with mild disease.|
|Appears in Collections:||Master|
The Institute of Health Policy, Management and Evaluation - Master theses
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