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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18226

Title: Synthesis and Characterization of Citrate and Polymer Stabilized Lanthanide Trifluoride Nanoparticles
Authors: Alvares, Rohan
Advisor: Prosser, Robert Scott
Macdonald, Peter Moore
Department: Chemistry
Keywords: nanoparticle
lanthanide
citrate
poly(acrylic acid)
MRI
contrast agent
NMR
diffusion
gadolinium
Issue Date: 7-Jan-2010
Abstract: Citrate-coated gadolinium trifluoride (Cit-GdF3) and poly(acrylic acid)-coated nanoparticles (PAA-GdF3 NPs) were synthesized, the former reproduced from literature (though using more refined conditions), the latter through a new, two-step, ligand exchange method. Diamagnetic nanoparticle analogs (Cit-YF3 NPs) were prepared to investigate citrate interactions with the nanoparticle surface using NMR. Citrate was found to bind in numerous conformations, with a total of between 29 – 46 % bound at 0 ºC. Exchange studies revealed short residence lifetimes of one and twelve seconds respectively for bound and free forms of citrate (0 ºC), perhaps explaining the colloidal instability of these nanoparticles. PAA-GdF3 NPs were synthesized by first producing their Cit-GdF3 counterparts, and then exchanging citrate for PAA. The impetus behind this latter synthesis was the relative enhancement in stability and relaxivity attainable by these nanoparticles. The displacement of citrate by PAA was verified using diffusion NMR studies.
URI: http://hdl.handle.net/1807/18226
Appears in Collections:Master
Department of Chemistry - Master theses

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