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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18257

Title: The Role of Dopamine in Cue-induced Craving: A [11C]-(+)-PHNO PET Study in Tobacco-dependent Smokers
Authors: Chiuccariello, Lina
Advisor: Busto, Usoa
Le Foll, Bernard
Department: Pharmacology
Keywords: dopamine
Issue Date: 13-Jan-2010
Abstract: Environmental stimuli associated with drug use are related to drug craving and relapse. The mechanism of cue-induced craving is thought to involve the release of dopamine (DA) in brain regions associated with reward and habit formation. The aim of the study was to investigate the role of DA in cue-induced craving in tobacco-dependent smokers using Positron Emission Tomography (PET) and a picture cue paradigm. Tobacco-associated cues were capable of eliciting significantly greater subjective reports of craving relative to neutral cues in tobacco smokers (n=6) in a neuroimaging environment. Using this cue paradigm and [11C]-(+)-PHNO PET (n=6), a non-significant trend towards a greater decrease in binding potential, indicative of dopamine release, was shown in selected brain regions of interest. These findings are similar to findings in cocaine-dependent individuals and suggest the involvement of dopamine in the response to smoking-associated cues in tobacco-dependent individuals.
URI: http://hdl.handle.net/1807/18257
Appears in Collections:Master
Department of Pharmacology and Toxicology - Master theses

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