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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18261

Title: Gene Expression Analysis of Flrt1, Flrt2 and Flrt3 in the Murine Midface during Early Embryogenesis
Authors: Chung, Karen Clare
Advisor: Peel, Sean
Gong, Siew-Ging
Department: Dentistry
Keywords: dentistry
gene expression
Issue Date: 13-Jan-2010
Abstract: The Fibronectin leucine-rich transmembrane (Flrt) gene family has been implicated in FGF signaling, which is crucial for coordinating craniofacial morphogenesis and epithelial mesenchymal interactions (EMI). The gene expression patterns of Flrt1, Flrt2 and Flrt3 were analyzed during critical stages of murine midfacial development from 9.5-15.5 dpc. Flrt2 and Flrt3 were observed to have unique expression patterns in the midface, whereas Flrt1 did not. From 10.5-12.5dpc, Flrt2 was expressed in the mesenchyme of the medial nasal process(MNP). Flrt3 was expressed in the mesenchyme of the lateral nasal process (LNP) and MNP. From 13.5-15.5dpc, Flrt2 was expressed in the oral ectomesenchyme of the palatal shelves, whereas Flrt3 was expressed in the medial edge and oral epithelium. Both Flrt2 and Flrt3 were expressed in different sites of the developing tooth buds and hair follicles. This suggests that Flrt2 and Flrt3 have unique roles during craniofacial morphogenesis, whereas Flrt1 may have a more generalized role.
URI: http://hdl.handle.net/1807/18261
Appears in Collections:Master
Faculty of Dentistry - Master theses

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