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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18274

Title: Sub-acute Hippocampal Atrophy in the First Year Following Moderate to Severe Traumatic Brain Injury
Authors: DeSouza, Danielle
Advisor: Green, Robin
Department: Rehabilitation Science
Keywords: TBI
Issue Date: 13-Jan-2010
Abstract: Rationale: Ng et al. (2008) demonstrated that sub-acute hippocampal atrophy occurred between 4.5 and 24 months following moderate-to-severe traumatic brain injury (TBI); it remains to be determined if atrophy occurred before 24 months. Objectives: (1) to determine if sub-acute hippocampal atrophy occurs by the first year of injury; (2) to determine associated clinical and demographic variables. Methods: Ten moderate-to-severe TBI patients underwent MRI at 5 and 12 months post-injury. Glasgow Coma Scale (GCS) and demographic variables were correlated with change. Results: Significant hippocampal volume decreases were observed for right (P< 0.002, Cohen’s d= 0.34) and left (P< 0.036, Cohen’s d= 0.22) sides. GCS was significantly correlated with right (r= -0.663, P< 0.037), but not left percent hippocampal volume change (r= -0.327, P< 0.356). No significant correlations were observed for demographic variables. Conclusion: Sub-acute hippocampal atrophy occurs between 5 and 12 months post-injury and is associated with injury severity.
URI: http://hdl.handle.net/1807/18274
Appears in Collections:Master
Graduate Department of Rehabilitation Science - Master theses

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