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|Title: ||Sulfonyl Chlorides as Versatile Reagents for Chelate-assisted C–H Bond Functionalizations|
|Authors: ||Dimitrijevic, Elena|
|Advisor: ||Dong, Vy Maria|
|Keywords: ||C-H bond functionalization|
transition metal catalysis
|Issue Date: ||14-Jan-2010|
|Abstract: ||Despite the great abundance of C–H bonds in readily available starting materials, their use in synthesis of functionalized molecules has been hampered by the high bond strengths, rendering them inert to common organic reagents. However, recent progress in the field has addressed this issue, enabling selective C–H bond functionalizations to be performed using catalytic transition metal mediated processes.
Herein, the use of sulfonyl chlorides as versatile reagents for C–H bond functionalizations is reported. Using chelation assistance, the regioselective conversion of C–H bonds to either C–S, C–Cl or C–C bonds was achieved. The methodology development, substrate scope determination and mechanistic investigations will be discussed.|
|Appears in Collections:||Master|
Department of Chemistry - Master theses
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