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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18280

Title: Sulfonyl Chlorides as Versatile Reagents for Chelate-assisted C–H Bond Functionalizations
Authors: Dimitrijevic, Elena
Advisor: Dong, Vy Maria
Department: Chemistry
Keywords: C-H bond functionalization
sulfonyl chlorides
transition metal catalysis
Issue Date: 14-Jan-2010
Abstract: Despite the great abundance of C–H bonds in readily available starting materials, their use in synthesis of functionalized molecules has been hampered by the high bond strengths, rendering them inert to common organic reagents. However, recent progress in the field has addressed this issue, enabling selective C–H bond functionalizations to be performed using catalytic transition metal mediated processes. Herein, the use of sulfonyl chlorides as versatile reagents for C–H bond functionalizations is reported. Using chelation assistance, the regioselective conversion of C–H bonds to either C–S, C–Cl or C–C bonds was achieved. The methodology development, substrate scope determination and mechanistic investigations will be discussed.
URI: http://hdl.handle.net/1807/18280
Appears in Collections:Master
Department of Chemistry - Master theses

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