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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18282

Title: Health Technology Assessment of Thiopurine Methyltransferase Testing for Guiding 6-Mercaptopurine Doses in Pediatric Patients with Acute Lymphoblastic Leukemia
Authors: Donnan, Jennifer
Advisor: Ungar, Wendy Joan
Department: Health Policy, Management and Evaluation
Keywords: Pharmacogenetics
Thiopurine Methyltransferase
Issue Date: 15-Jan-2010
Abstract: This study determined whether phenotype or genotype tests for thiopurine methyltransferase (TPMT) are cost effective interventions for guiding doses of 6-mercaptopurine in children with acute lymphoblastic leukemia (ALL) compared to standard weight-based dosing. A systematic review of the literature was conducted to assess the accuracy of the TPMT technologies, followed by a cost effectiveness analysis which compared genotype, phenotype and weight-based dosing strategies over a three month time horizon. Both TPMT phenotype and genotype technologies were considered accurate though there is no gold standard. Additionally, included studies were of low methodological quality. Neither of the interventions showed a benefit in survival and both were more costly compared to standard weight-based dosing. At this time there is insufficient evidence to recommend the use of phenotype or genotype testing prior to 6-mercaptopurine therapy to guide initial doses in pediatric ALL patients.
URI: http://hdl.handle.net/1807/18282
Appears in Collections:Master
The Institute of Health Policy, Management and Evaluation - Master theses

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