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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18303

Title: "Off-label" Prescribing of Gabapentin: An Exploratory Study
Authors: Fukuda, Nami Christine
Advisor: Kohler, Jillian Clare
Department: Pharmaceutical Sciences
Keywords: off-label
Issue Date: 18-Jan-2010
Abstract: “Off-label” use occurs when a medication is prescribed for non-approved purposes. This case study explored physician experiences with prescribing gabapentin off-label. Semi-structured interviews with 10 specialists in the Greater Toronto Area provided data that were analyzed using qualitative content analysis. Specialists described prescribing gabapentin off-label as common practice and few expressed concerns about its safety. Knowledge from various interconnected sources influenced off-label prescribing decisions. These included: social knowledge, scientific knowledge, knowledge of the drug, knowledge of the patient, and experiential knowledge. Findings were similar to previous studies examining physician prescribing behaviour. Furthermore, lack of provincial-government reimbursement for off-label uses of gabapentin (knowledge of drug coverage) was a significant barrier to prescribing. Off-label prescribing differs from other types of prescribing since there is often a lack of scientific evidence for off-label uses. The complexities of the off-label prescribing process and the degree of importance between the various influences require further exploration.
URI: http://hdl.handle.net/1807/18303
Appears in Collections:Master
Leslie L. Dan Faculty of Pharmacy - Master theses

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