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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18807

Title: Implementation of a Spatially-resolved Explicit Photodynamic Therapy Dosimetry System Utilizing Multi-sensor Fiber Optic Probes
Authors: Lai, Benjamin
Advisor: Lilge, Lothar
Department: Medical Biophysics
Keywords: Photodynamic Therapy
Spectroscopy
Dosimetry
Cancer
Issue Date: 15-Feb-2010
Abstract: Photodynamic Therapy (PDT) has proven to be a minimally invasive alternative treatment option for various conditions including cancer. The treatment efficacy of deep-seated tumours with PDT is variable, compared to the treatment of tissue surfaces such as the skin and esophagus. This is partly due to inadequate monitoring of the three interrelated treatment parameters: treatment light, photosensitizer and tissue oxygenation. This thesis presents the development of a system for explicit dosimetry of PDT treatment light and tissue oxygenation using multi-sensor fiber optic probes for spatially resolved parameter measurements. The system uses embedded fluorescent sensors for treatment light quantification. Tissue oxygenation measurement is accomplished using frequency domain techniques with embedded phosphorescent metalloporphyrin compounds as sensors.
URI: http://hdl.handle.net/1807/18807
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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