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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18808

Title: Poor Glycemic Control Predicts Increased Neuro-retinal Dysfunction in Adolescents with Type 1 Diabetes
Authors: Lakhani, Ekta
Advisor: Westall, Carol
Department: Medical Science
Keywords: diabetes
diabetic retinopathy
electrophysiology
electroretinogram
multifocal electroretinogram
slow flash multifocal electroretinogram
multifocal oscillatory potentials
type 1 diabetes
adolescents
hemoglobin A1c
retina
glycemic control
Issue Date: 15-Feb-2010
Abstract: Studies demonstrate localized neuro-retinal dysfunction in patients with diabetes and no visible diabetic retinopathy (DR). Poor glycemic control is a strong risk factor for DR. We hypothesized that poor glycemic control predicts increased areas of localized neuro-retinal dysfunction in patients with diabetes. Forty-eight adolescents with diabetes and 45 controls were tested using the standard (103 hexagons) multifocal electroretinogram (mfERG). Negative binomial regression analysis was conducted with number of abnormal hexagons (delayed responses) as the dependent variable and glycated hemoglobin (HbA1c), disease duration, age and sex as covariates. Results indicate that a one-unit increase in HbA1c predicts an 80% (p = 0.002) increase in the number of abnormal hexagons when controlling for age. Increased areas of neuro-retinal dysfunction are predicted by worsening glycemic control in patients with no visible DR. Standard mfERG may be useful in monitoring patients with diabetes and identifying those who may be at risk of developing DR.
URI: http://hdl.handle.net/1807/18808
Appears in Collections:Master
Institute of Medical Science - Master theses

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