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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18874

Title: Characterization of Perfluorocarbon Droplets for Focused Ultrasound Therapy
Authors: Schad, Kelly C.
Advisor: Hynynen, Kullervo
Department: Medical Biophysics
Keywords: focused ultrasound
perfluorocarbon droplets
Issue Date: 15-Feb-2010
Abstract: Focused ultrasound therapy can be enhanced with microbubbles by thermal and cavitation effects. However, localization of treatment becomes difficult as bioeffects can occur outside of the target region. Spatial control of gas bubbles can be achieved with acoustic vaporization of perfluorocarbon droplets. This study was undertaken to determine the acoustic parameters for bubble production by droplet vaporization and how it depends on the acoustic conditions and droplet physical parameters. Droplets of varying sizes were sonicated in vitro with a focused ultrasound transducer and varying frequency and exposure. Simultaneous measurements of the vaporization and inertial cavitation thresholds were performed. The results show that droplets cannot be vaporized at low frequency without inertial cavitation occurring. However, the vaporization threshold decreased with increasing frequency, exposure and droplet size. In summary, we have demonstrated that droplet vaporization is feasible for clinically-relevant sized droplets and acoustic exposures.
URI: http://hdl.handle.net/1807/18874
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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