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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18884

Title: Use of Meconium and Hair for Detection of Prenatal Exposure to Ethanol and Other Drugs of Abuse
Authors: Shor, Sarit
Advisor: Koren, Gideon
Department: Pharmacology
Keywords: Alcoholism
Drugs of abuse
Ethanol
FAEE
Meconium
Neonatal hair
Glucose
Issue Date: 15-Feb-2010
Abstract: In-utero ethanol exposure may result in fetal alcohol spectrum disorder (FASD). Studies have suggested that women who drink ethanol are more likely to consume illicit drugs. Detection of such exposures has been done via meconium and hair testing and can serve to direct needed prevention methods and appropriate management and intervention for the neonate and the mother. This study examined maternal diabetes as a possible confounder for in-utero ethanol exposure testing and determined the trends in drug use associated with heavy in-utero ethanol exposure in a high-risk obstetric Canadian population. It was determined that maternal diabetes does not produce false-positive results in testing for in-utero ethanol exposure. Furthermore, heavy in-utero ethanol exposure was detected in 15.5% of samples and was associated with an increased exposure to amphetamines (OR=3.30) and opiates (OR=2.01), but a decreased exposure to cannabinoids (OR=0.61) when compared to neonates with no heavy in-utero ethanol exposure.
URI: http://hdl.handle.net/1807/18884
Appears in Collections:Master
Department of Pharmacology and Toxicology - Master theses

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