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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18886

Title: A Technical and Clinical Assessment of Stereotactic Registration Techniques to Improve MRI Guided Needle Navigation in Prostate Cancer Targeting
Authors: Suljendic, Denis
Advisor: Menard, Cynthia
Department: Biomedical Engineering
Keywords: MRI-guided biopsy
stereotactic registration
prostate cancer
Issue Date: 15-Feb-2010
Abstract: Prostate cancer is prevalent among men and one of the few cancer sites where local therapies currently target the entire organ instead of tumour. MRI holds promise in accurately depicting regions of cancer burden within the prostate gland and guiding tumour-targeted diagnostics and therapeutics. The clinical performance of a novel stereotactic MRI-guided needle navigation system for prostate cancer targeting was evaluated. Mean absolute in-plane stereotactic needle-targeting error for 10 patients was 2.2 mm and mean absolute depth error was 6.5 mm, highlighting a need to improve technical accuracy of the system. Consequently, alternative stereotactic registration techniques were investigated. Metrics of performance were in-plane stereotactic needle-targeting error, depth error, and registration time. A Z-shaped fiducial motif using automated registration performed best in phantom experiments with an in-plane error of 2.0 mm and depth error of 1.0 mm. These results will guide further software and hardware development to improve clinical performance.
URI: http://hdl.handle.net/1807/18886
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

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