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T-Space at The University of Toronto Libraries >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18889

Title: Scattering of High-frequency Ultrasound by Individual Bound Microbubbles
Authors: Sprague, Michael
Advisor: Foster, F. Stuart
Department: Medical Biophysics
Keywords: High-frequency ultrasound
Microbubbles
Molecular imaging
Subharmonic signal
Issue Date: 15-Feb-2010
Abstract: Targeted imaging with microbubbles may resolve the molecular expression within the abnormal blood vessels of tumours. Optimal imaging requires understanding the interaction between targeted microbubbles and high-frequency ultrasound. Therefore, the subharmonic signal, and backscattering cross-section of individual bound microbubbles were examined with coaligned 30 MHz pulses and optical images. The peak subharmonic signal was generated for 1.6 µm diameter microbubbles for 20% and 11% bandwidth pulses and 1.8 µm for 45% bandwidth pulses at 200 kPa, consistent with estimations of the resonant size of microbubble's at 15 MHz. In order to measure the scattering cross-section, a new method was proposed to measure the receive transfer function of a transducer. Measurements of the backscattering cross-section scaled with the square of the radius, with signi cant size-independent variability. The results of this thesis will help optimise the parameters for targeted imaging, as well as further our understanding of the behaviour of microbubbles.
URI: http://hdl.handle.net/1807/18889
Appears in Collections:Master
Department of Medical Biophysics - Master theses

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