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T-Space at The University of Toronto Libraries >
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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18896

Title: A Computer Controlled Endorectal Cooling Device for Laser Thermal Therapy
Authors: Metias, Maged Maher
Advisor: Weersink, Robert
Trachtenberg, John
Department: Biomedical Engineering
Keywords: Prostate Cancer
Laser Thermal Therapy
Rectal Cooling
Peltier
Issue Date: 15-Feb-2010
Abstract: Interstitial laser thermal therapy is a novel local approach to treating prostate cancer. During treatment, thermal ablation may occur on the adjacent rectal wall. The aim of this thesis was therefore twofold: to study the effects of rectal cooling on lesion formation, and secondly, to engineer a computer controlled rectal cooling unit. To study the effects of the coolant temperatures and flow rate, thermal simulations were executed, followed by testing the phenomenon using agar gel phantoms which thermally mimic prostate tissue. Further simulations were run using a treatment planning software, which predicted the required coolant temperatures to protect the outer rectal wall while subsequently determining the shape and size of the resulting coagulated lesion at various laser settings. Results suggest that low coolant temperatures and low flow rates cause maximum cooling rates. Furthermore, the shape and size of the coagulated region is affected by coolant temperatures at specific laser powers and positions within the prostate.
URI: http://hdl.handle.net/1807/18896
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

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