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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18900

Title: Olanzapine-induced Weight Gain: An Animal Model
Authors: Mann, Stephen Wallace
Advisor: Remington, Gary
Department: Medical Science
Keywords: olanzapine
weight gain
food intake
locomotor activity
Issue Date: 15-Feb-2010
Abstract: Introduction: Using an animal model, we examined weight gain in rats exposed to olanzapine, as well as whether increased weight was associated with food intake, visceral fat and/or locomotion. Methods: Sprague-Dawley rats were chronically treated with olanzapine while being offered diets including standard chow, a high fat (60% fat) diet, and a high fat/high carbohydrate (42% fat; 42.7% carbohydrate) diet. Body weight, food intake, visceral fat and locomotor activity were measured. Results: Our findings related to weight gain are in line with other reports indicating that while olanzapine-induced weight gain can be observed, it does not mirror what is observed in humans on two levels: (i) it is not of the same magnitude, and (ii) it is more gender specific i.e., females greater than males. Conclusions: These data confirm that chronic treatment with olanzapine has varying effects on weight gain, food intake, visceral fat and locomotor activity.
URI: http://hdl.handle.net/1807/18900
Appears in Collections:Master
Institute of Medical Science - Master theses

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