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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18908

Title: The Role of Notch Signaling in Learning and Memory
Authors: Marsolais, Alexander John
Advisor: Josselyn, Sheena
Department: Physiology
Keywords: memory
Notch
Issue Date: 15-Feb-2010
Abstract: The Notch receptor and its ligands constitute a ubiquitous signaling pathway found throughout all multicellular animal life. In addition to its highly conserved function in development, a growing body of evidence suggests Notch signaling has important roles to play in adult processes, including long-term memory (LTM) formation. Building on previous work showing a specific requirement for the Notch1 receptor in spatial memory in mice, I show here a similar requirement for the Notch ligand Jag1. Mice with mutations to Dll1 (another Notch ligand) and Lfng (a Notch regulatory protein) do not display such phenotypes. I propose a model in which signaling between Notch pathway components found in the adult mouse hippocampus (such as Notch1 and Jag1) is required for LTM encoding, with no requirement for pathway components not expressed in this tissue (such as Dll1 and Lfng).
URI: http://hdl.handle.net/1807/18908
Appears in Collections:Master
Department of Physiology - Master theses

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