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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18926

Title: The Molecular and Genetic Interactions Between Pax3 and Alx4
Authors: Mojtahedi, Golnessa
Advisor: Hamel, Paul A.
Department: Laboratory Medicine and Pathobiology
Keywords: Pax3
Alx4
Protein-Protein Interactions
Issue Date: 15-Feb-2010
Abstract: Alx4 is a paired-type homeodomain transcription factor that plays a key role in development, strongly expressed in the first branchial arch and craniofacial region. Pax3 also belongs to this family, and it displays a similar pattern of expression to that of Alx4. When Pax3 or Alx4 activity is lost individually, defects arise in an overlapping set of embryonic structures. In addition to their expression patterns, this suggests that these two factors may interact to play a role in normal murine development. We demonstrate an overlapping pattern of expression of Pax3 and Alx4 in the developing embryo and that Pax3 and Alx4 physically interact in vivo and in vitro. Pax3 and Alx4 can activate transcription from a P3 homeodomain consensus site, and preliminary analysis of mice null for both Pax3 and Alx4 show a novel mutant phenotype. We have therefore demonstrated a physical and genetic interaction between Pax3 and Alx4.
URI: http://hdl.handle.net/1807/18926
Appears in Collections:Master
Department of Laboratory Medicine and Pathobiology - Master theses

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