T-Space at The University of Toronto Libraries >
School of Graduate Studies - Theses >
Please use this identifier to cite or link to this item:
|Title: ||Genetic and Serolgical Markers Associated with Pouchitis and a Crohn's Disease-like Phenotype after Pelvic Pouch Surgery for Ulcerative Colitis|
|Authors: ||Verbeeten, Diane|
|Advisor: ||Silverberg, Mark|
|Department: ||Medical Science|
|Issue Date: ||16-Feb-2010|
|Abstract: ||Objective: Study the clinical, genetic and serological factors associated with new onset ileal inflammation in ulcerative colitis (UC) patients who have undergone ileal pouch-anal anastomosis (IPAA).
Methods: Retrospective assessment of UC patients registered in the MSH surgical database, questionnaire, chart review and serological and genetic analysis of blood sample.
Results: There was a positive association between gASCA antibodies, anti-L, smoking status and axial arthritis/ankylosing spondylits with a Crohn’s Disease (CD)-like phenotype post-op in UC/IPAA patients. Associations between alleles of selected genes including ECM1, PTPN2, and CD14 and post-operative phenotype were identified.
Conclusions: gASCA is typically associated with CD rather than UC which raises the possibility that gASCA positivity may delineate a subset of UC patients at risk for developing a CD-like phenotype after IPAA. The identification of genotype/phenotype associations in UC/IPAA will help to find those at risk for poor post-operative outcome. Prospective studies are needed to confirm these findings.|
|Appears in Collections:||Master|
Institute of Medical Science - Master theses
This item is licensed under a Creative Commons License
Items in T-Space are protected by copyright, with all rights reserved, unless otherwise indicated.