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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18951

Title: Genetic and Serolgical Markers Associated with Pouchitis and a Crohn's Disease-like Phenotype after Pelvic Pouch Surgery for Ulcerative Colitis
Authors: Verbeeten, Diane
Advisor: Silverberg, Mark
Department: Medical Science
Keywords: serological
Issue Date: 16-Feb-2010
Abstract: Objective: Study the clinical, genetic and serological factors associated with new onset ileal inflammation in ulcerative colitis (UC) patients who have undergone ileal pouch-anal anastomosis (IPAA). Methods: Retrospective assessment of UC patients registered in the MSH surgical database, questionnaire, chart review and serological and genetic analysis of blood sample. Results: There was a positive association between gASCA antibodies, anti-L, smoking status and axial arthritis/ankylosing spondylits with a Crohn’s Disease (CD)-like phenotype post-op in UC/IPAA patients. Associations between alleles of selected genes including ECM1, PTPN2, and CD14 and post-operative phenotype were identified. Conclusions: gASCA is typically associated with CD rather than UC which raises the possibility that gASCA positivity may delineate a subset of UC patients at risk for developing a CD-like phenotype after IPAA. The identification of genotype/phenotype associations in UC/IPAA will help to find those at risk for poor post-operative outcome. Prospective studies are needed to confirm these findings.
URI: http://hdl.handle.net/1807/18951
Appears in Collections:Master
Institute of Medical Science - Master theses

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