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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18958

Title: The Effects of Stress and Placebo Alcohol on Cognitive Activation and Inhibitory Control in Male Problem Drinkers and Healthy Controls
Authors: Tremblay, Anne-Marie
Advisor: Zack, Martin
Department: Pharmacology
Keywords: clinical pharmacology
problem drinkers
addiction
Issue Date: 16-Feb-2010
Abstract: This study assessed the separate and combined effects of two important instigators of relapse, alcohol cues and stress, on the salience of alcohol target stimuli and inhibitory control, in 12 male problem drinkers and 16 male controls. Subjects underwent two test sessions where they received alcohol cues (non-alcoholic beer) and/or stress (uncontrollable noise) in a counterbalanced manner. Testing was carried out through validated, computer-based tasks: modified Stroop, gambling-word Shift task; and conventional and modified (Alcohol word) Stop-Signal tasks. Inhibitory control was preferentially impaired to Alcohol stimuli in both groups. Beer and stress in combination increased incentive salience of Alcohol stimuli and moderated self-reported desire for alcohol in problem drinkers but not controls. Results suggest that alcohol cues and stress have interactive effects on subjective motivation, and disinhibit behaviour due to distraction in problem drinkers. Findings from this paradigm may improve understanding and facilitate treatment for relapse prevention in problem drinkers.
URI: http://hdl.handle.net/1807/18958
Appears in Collections:Master
Department of Pharmacology and Toxicology - Master theses

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