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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/18968

Title: Histone Deacetylase Inhibitor MS-275 Inhibits Neuroblastoma Cell Growth by Inducing Cell Cycle Arrest, Apoptosis, Differentiation and by Targeting its Tumor Stem Cell Population
Authors: Tsui, Micky Ka Hon
Advisor: Yeger, Herman
Department: Laboratory Medicine and Pathobiology
Keywords: Cancer
Histone Deacetylase Inhibitor
Neuroblastoma
cancer stem cell
side population
Issue Date: 16-Feb-2010
Abstract: Objective: MS-275, a phase trialed histone deacetylase inhibitor will be characterized for its ability reduce neuroblastoma (NB) viability and to target the tumor stem cell (TSC) population in neuroblastoma. Methods: Ability of MS-275 to reduce NB growth is characterized using a tumorigenic NB N-type cell line that has high differentiation potential. TSC enriched side population from NB and a reference teratocarcinoma cell line was analyzed as a model of TSC. The potential of MS-275 to modulate functional characteristics and markers of TSC was also investigated. Results: MS-275 induces a G1 cell cycle arrest, the intrinsic apoptosis pathway in NB and can potentially differentiate NB into a more terminal phenotype. NB TSC-like population is reduced following MS-275 treatment by the targeting of their self-renewal and drug pumping ability. Conclusions: By targeting both the NB and its TSC population, MS-275 has therapeutic potential for neuroblastoma. This warrants further in-vivo investigations.
URI: http://hdl.handle.net/1807/18968
Appears in Collections:Master
Department of Laboratory Medicine and Pathobiology - Master theses

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