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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/19004

Title: Characterization of a Biodegradable Electrospun Polyurethane Nanofiber Scaffold Suitable for Annulus Fibrosus Tissue Engineering
Authors: Yeganegi, Masoud
Advisor: Santerre, J. Paul
Kandel, Rita A.
Department: Biomedical Engineering
Keywords: intervertebral disc
annulus fibrosus
mechanical stimulation
biodegradation
tissue engineering
scaffold
nanofiber
degenerative disc
tissue engineering
Issue Date: 17-Feb-2010
Abstract: The current study characterizes the mechanical and biodegradation properties of a polycarbonate polyurethane (PU) electrospun nanofiber scaffold intended for use in the growth of a tissue engineered annulus fibrosus (AF) intervertebral disc component. Both the tensile strength and initial modulus of aligned scaffolds were higher than those of random scaffolds and remained unaffected during a 4 week biodegradation study, suggesting a surface-mediated degradation mechanism. The resulting degradation products were non-toxic. Confined compressive mechanical force of 1kPa, was applied at 1Hz to in vitro bovine AF tissue grown on the scaffolds to investigate the influence of mechanical force on AF tissue production, which was found to decrease significantly at 72 hours relative to 24 hours, independent of any effects from mechanical forces. Overall, the consistent rate of PU degradation, along with mechanical properties comparable to those of native AF tissue, and the absence of cytotoxic effects, make this polymer suitable for further investigation for use in tissue-engineering the AF.
URI: http://hdl.handle.net/1807/19004
Appears in Collections:Master
Institute of Biomaterials and Biomedical Engineering - Master theses

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