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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/19312

Title: The Relationship Between Insulin Resistance and Hyperinsulinemia on Mammary Cancer Growth and Development
Authors: Khalid, Sarah
Advisor: Fantus, I. George
Department: Physiology
Keywords: Hyperinsulinemia
Breast Cancer
Issue Date: 4-Mar-2010
Abstract: Insulin resistance associated with obesity has been suggested to contribute to an increased risk and poor prognosis for breast cancer. In this study, a HER2/Neu transgenic mouse model of breast cancer was used to assess how obesity-induced insulin resistance and hyperinsulinemia can influence the development and progression of breast cancer. We investigated the effect of a high-fat diet and found a tumor-promoting effect in the absence of overt insulin resistance. In contrast, a high-fat combined with fructose diet induced significant hyperinsulinemia but no tumor promoting or growth effect was observed. Treatment with the anti-diabetic, insulin-lowering agent metformin led to a delay in tumor onset in mice on control diet, but this effect was abrogated by the high-fat fructose diet. These data indicate that the effects and potential interactions of insulin, nutrition and drugs on breast cancer development and progression are complex and require further study.
URI: http://hdl.handle.net/1807/19312
Appears in Collections:Master
Department of Physiology - Master theses

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