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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/19475


Title: Circulating antigens levels in different clinical forms of the Schistosoma mansoni infection
Authors: Pereira e Silva, Yerkes
Secor, Evan
Andrade, Marcela Orsine
Katz, Naftale
Rabello, Ana
Keywords: Schistosoma mansoni - circulating antigens - diagnosis - ELISA
Issue Date: 31-Dec-1999
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 94 Num 1
Abstract: With the aim to evaluate the circulating cathodic antigen (CCA) levels in relation to the different clinical phases of Schistosoma sp. infection a sandwich ELISA using monoclonal antibody 5H11 was performed. The sera of three groups of 25 Brazilian patients with acute, intestinal and hepatosplenic forms of S. mansoni infection were tested and compared to a non-infected control group. Patients and control groups were matched for age and sex and the number of eggs per gram of feces was equally distributed among the three patient groups. Sensitivity of 100%, 72%, 52% of the assay was observed for the intestinal, hepatosplenic and acute toxemic groups respectively. The specificity was 100%. Intestinal and hepatosplenic groups presented CCA levels significantly higher in comparison to those observed for acute patients (F-ratio = 2,524; p = 0.000 and F-ratio = 6,314; p = 0.015 respectively). There was no significant difference of CCA serum levels between hepatosplenic and intestinal groups (F-ratio = 1,026; p = 0.316).
URI: http://hdl.handle.net/1807/19475
Other Identifiers: http://www.bioline.org.br/abstract?id=oc99017
Rights: Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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