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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/19560

Title: Specific antibody levels and antigenic recognition of Wistar rats inoculated with distinct isolates of Trypanosoma evansi
Authors: Queiroz, Adriana O.
Legey, Ana Paula
Xavier, Samanta Cristina das Chagas
Jansen, Ana Maria
Keywords: Trypanosoma evansi, Wistar rats, antigenic recognition, indirect fluorescent antibody test
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num 7
Abstract: "Mal de Cadeiras", an enzootic disease caused by Trypanosoma evansi   , is one of the most important trypanosomiases in the Brazilian Pantanal region. The disease affects mainly horses, which are widely used in extensive cattle production, an activity of greatest economical significance for the region. The parasite also infects sylvan (coatis and capybaras) and domestic (dogs) animals, respectively considered wild and domestic reservoirs of T. evansi. For a better understanding of the interaction of T. evansi with its rodent host, we evaluated the differences in the specific antibody level patterns and in the parasitic peptides recognition patterns of experimentally infected Wistar rats. The rats experimentally infected with T. evansi isolates obtained from coatis, dogs and horses were submitted to indirect immunofluorescence test (IgM e IgG) and Western blotting. The serological titers for IgM and IgG ranged between 1:40 and 1:160. The most recognized polypeptide profiles were in a range of 17 and 74 kDa. Our data suggest that the humoral immune response in Wistar rats is not sufficient for granting an effective control of T. evansi infections.
URI: http://hdl.handle.net/1807/19560
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01188
Rights: Copyright 2001 Instituto Oswaldo Cruz - Fiocruz.
Appears in Collections:Bioline International Legacy Collection

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