|Title: ||Laboratory and Field Evaluation of Biodegradable Polyesters for Sustained Release of Isometamidium and Ethidium - Minireview|
|Authors: ||Geerts, S.|
Brandt, J. R. A.
De Deken, R.
|Keywords: ||review - isometamidium - ethidium - sustained release - prophylaxis -
trypanosomiasis - cattle|
|Issue Date: ||31-Dec-1999|
|Publisher: ||Fundação Oswaldo Cruz, Fiocruz|
|Citation: ||Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 94 Num 2|
|Abstract: ||An overview is presented of the results obtained with biodegradable
sustained release devices (SRDs) containing a mixture of polymers and
either isometamidium (ISMM) or ethidium. Under controlled laboratory
conditions (monthly challenge with tsetse flies infected with
Trypanosoma congolense) the protection period in SRD treated cattle
could be extended by a factor 2.8 (for ethidium) up to 4.2 (for ISMM)
as compared to animals treated intramuscularly with the same drugs.
Using a competitive drug ELISA ISMM concentrations were detected up to
330 days after the implantation of the SRDs, whereas after i.m.
injection the drug was no longer present three to four months post
treatment. Two field trials carried out in Mali under heavy tsetse
challenge showed that the cumulative infection rate was significantly
lower in the ISMM-SRD implanted cattle than in those which received
ISMM intramuscularly. Using ethidium SRD, however, contradictory
results were obtained in field trials in Zambia and in Mali. The
potential advantages and inconvenients of the use of SRDs are discussed
and suggestions are made in order to further improve the currently
|Other Identifiers: ||http://www.bioline.org.br/abstract?id=oc99041|
|Rights: ||Copyright 1999 Fundacao Oswaldo Cruz - Fiocruz|
|Appears in Collections:||Bioline International Legacy Collection|