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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/1995

Title: ARTICULO ORIGINAL COMPLETO/FULL ORIGINAL PAPER - IMMUNITY AND PROTECTION ELICITED BY A RECOMBINANT VACCINE AGAINST ENTEROTOXIGENIC E. coli.
Authors: Wong, Idania
Moreno, Milton
Molerio, Maria del C.
Valderrama, Susset
Joglar, Marisdania
Horrach, Massiel
Bover, Eddy
Borroto, Aldo
Basulto, Roberto
Calzada, Lesvia
Hernandez, R.
Herrera, Luis
de la Fuente, Jose
Keywords: Biotechnology
Enterotoxigenic E. coli, colibacillosis, vaccine, fimbriae, K88, K99 ba95002
Issue Date: 1995
Publisher: Elfos Scientiae
Citation: Biotecnologia Aplicada 12(1)
Abstract: We studied the effectiveness of a recombinant vaccine capable of protecting piglets from enterotoxigenic E. coli during lactation and after weaning. Following this purpose, we vaccinated some pregnant sows with the recombinant vaccine VACOLI^TM (Heber Biotec S.A, P.O.Box 6162, Havana, CUBA), composed of enterotoxigenic E. coli K88ab and K99 recombinant antigens, plus an oil adjuvant. Before weaning piglets were reimmunized to extend protection, and serum samples were tested by an enzyme-linked immunoassay in solid phase to determine the antibody levels against K88ab and K99. The control of E. coli infections was performed by plating stool samples in selective media. There were no death recorded in piglets from vaccinated sows by collibacillosis during lactation, while in piglets from the control sows mortality was of 21%. The morbility and the number of deaths by other causes in the vaccinated group were significantly lower than in the control group. Total protection achieved was 93%. After weaning, mortality caused by E. coli was 0.37% in the vaccinated group of piglets and 21.7% in the control group. The total protection in this period was 98%. RESUMEN Para estudiar la efectividad de una vacuna recombinante capaz de proteger a cerdos contra la E. coli enterotoxica durante la lactancia y despues del destete, se realizo la vacunacion de cerdas gestantes con la vacuna recombinante VACOLI^TM
URI: http://bioline.utsc.utoronto.ca/archive/00000993/01/ba95002.pdf
http://hdl.handle.net/1807/1995
Appears in Collections:Bioline International Legacy Collection

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