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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/20119


Title: Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response
Issue Date: 31-Dec-1997
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 92 Num S1
Abstract: Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 92, Suppl. II, pp. 147-155 Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response Joao PB Viola, Anjana Rao Code Number:OC97180 Size of Files: Text: 44.6K Graphics: Line drawings and photographs (jpg) - 60.2K Proteins belonging to the NFAT (nuclear factor of activated T cells) family of transcription factors are expressed in most immune cell types, and play a central role in the transcription of cytokine genes, such as IL-2, IL-4, IL-5, IL-13, IFN-gamma, TNF-alpha, and GM-CSF. The activity of NFAT proteins is regulated by the calcium/calmodulin-dependent phosphatase calcineurin, a target for inhibition by CsA and FK506. Recently, two different groups have described that mice lacking the NFAT1 transcription factor show an enhanced immune response, with tendency towards the development of a late Th2-like response. This review evaluates the possible role of NFAT proteins in the Th2 immune response and in the eosinophil-mediated allergic response. Key words: nuclear factor of activated T cells - interleukin - cyclosporin Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz
URI: http://hdl.handle.net/1807/20119
Other Identifiers: http://www.bioline.org.br/abstract?id=oc97180
Rights: Copyright 1997 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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