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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/20179

Title: SHORT COMMUNICATION - Dissociation between Vasodilation and Leishmania Infection-enhancing Effects of Sand Fly Saliva and Maxadilan
Authors: Castro-Sousa, Fábio
Paranhos-Silva, Moacir
Sherlock, Ítalo
Paixão, Mariza S.
Pontes-de-Carvalho, Lain C.
dos-Santos, Washington L. C.
Keywords: Lutzomyia longipalpis saliva, maxadilan, Leishmania major, Leishmania braziliensis, vasodilation
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num 7
Abstract: In this study, the ability of maxadilan and Lutzomyia longipalpis   salivary gland lysate to enhance the infection of CBA mice by Leishmania major   and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania   alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments.
URI: http://hdl.handle.net/1807/20179
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01193
Rights: Copyright 2001 Instituto Oswaldo Cruz - Fiocruz.
Appears in Collections:Bioline International Legacy Collection

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