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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/20506


Title: Cytokine responses to dengue infection among Puerto Rican patients
Authors: Kuno, Goro
Bailey, Raymond E.
Keywords: dengue - cytokine - interleukin-1- interleukin-6 - tumor necrosis factor
Issue Date: 31-Dec-1994
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 89 Num 2
Abstract: Recently, a strong correlation between high concentration of tumor necrosis factor (TNFa) in blood and severity of dengue hemorrhagic fever/dengue shock syndrome has been reported from Asia and the Pacific. We wished to determine if a similar relationship could be found in dengue patients in the Americas where adult patients with severe syndromes have been observed more frequently than in Asia where severe cases have been observed mostly among children. The concentrations of interleukin-1 (IL-1beta) in hospistalized adult groups were significantly lower than that in outpatient adults. In contrast, the levels of interleukin 6 (IL-6) were significantly higher in hospitalized adults and children than in the corresponding outpatients. Levels of TNFa were higher in hospistalized children than in outpatient children or hospistalized adults. There was no significant difference in the levels of these three cytokines among hospitalized patients with or without hemorrhagic manifestations. Thus, an elevated IL-6 level was positively associated with severity of dengue infection in both children and adults, but IL-1beta level was negatively associated with severity in adults.
URI: http://hdl.handle.net/1807/20506
Other Identifiers: http://www.bioline.org.br/abstract?id=oc94037
Rights: Copyright 1994 Memorias do Instituto Oswaldo Cruz.
Appears in Collections:Bioline International Legacy Collection

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