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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/20631


Title: Multiple isolates from Aids patients: Aspects of an analysis by a genotypic marker and antimicrobial susceptibilities variations
Authors: Saad, Maria Helena Feres
Telles, Maria Alice
Porfirio, Fatima
Ferrazoli, Lucilaine
Fonseca, Leila de Souza
Johnson Jr., Warren
Riley, Lee W.
Keywords: Mycobacterium avium, polyclonal infection, susceptibility test
Issue Date: 31-Dec-2000
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 95 Num 5
Abstract: Twenty-one Mycobacterium avium multisolates, from ten human immunodeficiency virus-infected patients, were typed by restriction fragment length polymorphism using as marker the IS1245 and characterized by minimum inhibitory concentration for nine different antibiotics. Two out of four patients harboring multisolates with different fingerprint profile, were therefore considered as having a polyclonal infection, since their isolates were taken from sterile site. This result confirms that polyclonal infection caused by M. avium occurs with a nonnegligenciable frequency. Analyzing the multisolates susceptibility profile of each patient it was observed that most of them were infected with strains having appreciably different antimicrobial susceptibility patterns, no matter what the genotypic pattern of the strains was. These results have strong implication for the treatment of the patients.
URI: http://hdl.handle.net/1807/20631
Other Identifiers: http://www.bioline.org.br/abstract?id=oc00115
Rights: Copyright 2000 Fundacao Oswaldo Cruz Fiocruz
Appears in Collections:Bioline International Legacy Collection

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