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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21135

Title: Cytokines in the modulation of eosinophilia
Issue Date: 31-Dec-1997
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 92 Num S1
Abstract: Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 92 (Suppl.II), 1997, pp.109-114 Cytokines in the modulation of eosinophilia Lucia H Faccioli, BB Vargaftig, Alexandra I Medeiros, Adriana Malheiros Code Number:OC97175 Size of Files: Text: 21.7K Graphics: Line drawings and photographs (jpg) - 87.5K Tables (jpg) - 60.4K In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection, and the interaction between these cytokines and IL-5 during infection. Finally we propose a new biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion. Key words: eosinophils - helminth Parasites - inflammation - cytokines Copyright 1997 Fundacao Oswaldo Cruz - Fiocruz
URI: http://hdl.handle.net/1807/21135
Other Identifiers: http://www.bioline.org.br/abstract?id=oc97175
Rights: Copyright 1997 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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