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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21152

Title: Zinc Sulphate in the Treatment of Cutaneous Leishmaniasis: an in Vitro and Animal Study
Authors: Najim, Rafid A.
Sharquie, Khalifa E.
Farjou, Imad B.
Keywords: cutaneous leishmaniasis - Leishmania major - Leishmania tropica - axenic amastigotes - mice - zinc sulphate
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num 6
Abstract: This study was designed to evaluate the effectiveness of zinc sulphate both in vitro and in an animal model against both strains of old world cutaneous leishmaniasis. The in vitro sensitivities of promastigotes and axenic amastigotes of both Leishmania major and L. tropica to zinc sulphate was determined, the LD50 calculated and compared to the standard treatment for cutaneous leishmaniasis pentavalent antimony compounds. The results show that the two forms of both strains were sensitive to zinc sulphate and their respective LD50 were lower compared to the pentavalent antimony compound. Furthermore the sensitivities of the forms of both strains were tested using a simple slide method and compared to results of the standard method. To confirm this result, zinc sulphate was administered orally to mice infected with cutaneous leishmaniasis both therapeutically and prophylactically. Results showed that oral zinc sulphate was effective in both treatment and prophylaxis for cutaneous leishmaniasis. These results encourage the use of oral zinc sulphate in the treatment of cutaneous leishmaniasis clinically.
URI: http://hdl.handle.net/1807/21152
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98220
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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