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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21387


Title: TT Virus Infection in Children and Adults who Visited a General Hospital in the South of Brazil for Routine Procedure
Issue Date: 31-Dec-2001
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 96 Num 4
Abstract: Mem Inst Oswaldo Cruz 2001, Volume 96, Number 4, pp. 519-522 TT Virus Infection in Children and Adults who Visited a General Hospital in the South of Brazil for Routine Procedure Helena CF Vasconcelos, Maria E Menezes, Christian Niel Code Number: oc01079 ABSTRACT: TT virus (TTV) is a newly described nonenveloped human virus, with a circular, negative-stranded DNA genome, that was first identified in the blood of a patient with posttransfusion hepatitis of unknown etiology. PCR primers and conditions used for TTV DNA amplification may greatly influence the level of TTV detection in serum. Three PCR assays, with different regions of the genome as targets, were used to test TTV DNA in 130 sera from children and adults visiting a hospital in the south of Brazil, most of them for routine procedure. Forty-four percent of adult sera and 73% of sera from children aged 0-10 years were TTV positive with at least one PCR assay. However, the three assays were able to detect only 33%, 35%, and 70% of the total positive samples. Our results showed a high prevalence of TTV infection in the south of Brazil, particularly among young children, and confirmed the necessity of performing several PCR assays to assess the true TTV prevalence in a determined population. KEYWORDS: liver disease, novel virus, polymerase chain reaction, prevalence, TTV DNA Copyright 2001 Mem Inst Oswaldo Cruz
URI: http://hdl.handle.net/1807/21387
Other Identifiers: http://www.bioline.org.br/abstract?id=oc01079
Rights: Copyright 2001 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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