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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21433


Title: RESEARCH NOTE - Characterization of an Abundant Schistosoma mansoni Transcript with No Homologs in the Databases
Authors: Meira, Wendell Sérgio Ferreira
Franco, Glória Regina
Rabelo, Élida Mara Leite
Pena, Sérgio Danilo Junho
Keywords: Schistosoma mansoni - expressed sequence tags - database searches - reverse transcribed-polymerase chain reaction
Issue Date: 31-Dec-1998
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 93 Num s1
Abstract: The expressed sequence tag (EST) approach that we have used in the Schistosoma mansoni Genome Project is a powerful technique for the discovery of new genes of the parasite. In a recent comparative study of gene expression in distinct developmental stages of the parasite life cycle using the EST strategy, we identified 466 different genes. From this total, 427 were novel and 333 of them could not be identified based on homologies with database sequences. The high frequency of some of these "unknown" genes in different cDNA libraries suggests that they might have important roles in the biology of S. mansoni and thus may constitute possible targets for drug design or vaccine production. One of these genes, highly abundant in one of four adult worm libraries that we are studying in our laboratory, was selected for further characterization.
URI: http://hdl.handle.net/1807/21433
Other Identifiers: http://www.bioline.org.br/abstract?id=oc98170
Rights: Copyright 1998 Fundacao Oswaldo Cruz - Fiocruz
Appears in Collections:Bioline International Legacy Collection

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