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Please use this identifier to cite or link to this item: http://hdl.handle.net/1807/21477

Title: A laboratory-based approach to biological control of snails
Issue Date: 31-Dec-1997
Publisher: Fundação Oswaldo Cruz, Fiocruz
Citation: Memórias do Instituto Oswaldo Cruz (ISSN: 1678-8060) Vol 92 Num 5
Abstract: Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 92(5), September/October 1997, pp. 661-662 A laboratory-based approach to biological control of snails Fred A Lewis, Matty Knight, Charles S Richards Code Number:OC97124 Sizes of Files: Text: 11.1K Graphics: No associated graphics files Development of Schistosoma mansoni in the intermediate host Biomphalaria glabrata is influenced by a number of parasite and snail genes. Understanding the genetics involved in this complex host/parasite relationship may lead to an often discussed approach of introducing resistant B. glabrata into the field as a means of biological control for the parasite. For the snail, juvenile susceptibility to the parasite is controlled by at least four genes, whereas one gene seems to be responsible for adult nonsusceptibility. Obtaining DNA from F2 progeny snails from crosses between parasite-resistant and-susceptible snails, we have searched for molecular markers that show linkage to either the resistant or susceptible phenotype. Both restriction fragment length polymorphism (RFLP) and random amplified polymorphic DNA (RAPD) approaches have been used. To date, using a variety of snail and heterologous species probes, no RFLP marker has been found that segregates with either the resistant or susceptible phenotype in F2 progeny snails. More promising results however have been found with the RAPD approach, where a 1.3 kb marker appears in nearly all resistant progeny, and a 1.1 kb marker appears in all susceptible progeny. Key words: snails - genetic susceptibility - biological control - schistosomiasis - Biomphalaria glabrata - Schistosoma mansoni - resistance - susceptibility Copyright 1997 Fundacao Oswaldo Cruz
URI: http://hdl.handle.net/1807/21477
Other Identifiers: http://www.bioline.org.br/abstract?id=oc97124
Rights: Copyright 1997 Fundação Oswaldo Cruz, Fiocruz
Appears in Collections:Bioline International Legacy Collection

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